Intravenous Infusions (100ml, 500ml, 1000ml & 3000ml)

What Kind of Pharmaceutical Products?

Parenteral drugs are formulated as solutions, suspensions, emulsions, liposomes, microspheres, nanosystems, and powders to be reconstituted as solutions. Parenteral dosage forms are different from any other type of pharmaceutical products for some characteristic values:

 

Standard IVF & Electrolites

 

Dialysys Solutions

 

TPN (Total Parenteral Nutrition)

 

Special Solutions

 

About CSP Products

Maintaining the correct level of fluid and electrolytes within the body (Homeostasis) is crucial for life. When some conditions influence normal fluid intake and output, the body may be at risk for dehydration.

The fast method of rehydration is through the injection of parenteral solutions into the body supply. The large majority of Compounded Sterile Preparations (CSPs) set by IV technicians are LVPs, large volume parenterals. Because these products are administered directly into the human blood supply, the solutions must possess certain chemical properties that render them safe for the patients. For example, the human blood plasma has a pH of 7,4 (slightly alkaline)and this value must be maintained for optimum health. In this regard, some facilities inject a buffer solution into the CSP, such as sterile sodium bicarbonate, to neutralize the pH and inhibit misaligned values.

The isotonic property means that the CSPs have relatively the same number of dissolved particles and the same osmotic pressure as human blood plasma (conversely: Hypertonic solutions-tipically TPN- contain a greater number of dissolved particles, Hypotonic solutions contain fewer dissolved particles). In light of potential hazards, CSP preparations must be in adherence to USP Chapter Guidelines (Pharmaceutical Compounding - Sterile Preparations) or other reference pharmacopoeias, as EP or JP.

 

IV Solutions: Large Volume Parenteral

Large-volume parenteral (LVP)-or,simply, LVPs-are sterile preparations of 250ml or greater that are administered parenterally. The most common LVPs are IV solutions compounded from a standard/base solution, such as 0.9% sodium chloride (known as NS, too), dextrose 5% in water (D5W), dextrose 5% in normal saline (D5NS), and Lactate Ringer (LR) solution.

These IV solutions can be administered as either a continuous infusion or a drip, a continuous infusion-also called a maintenance infusion, replacement infusion, or hydration infusion-typically consists of a base solution with additives, unlike continuous infusions, drip solutions are used to continuously deliver an IV medication to treat a specific medical condition. Note that the most common volumes for LVPs are 250ml, 500ml, and 100 ml, but BRAM-COR design can generate turnkey projects for any size, up to 5000ml for bags or canister.

 

IV Solutions: Small Volume Parenterals

According to reference pharmacopoeias, Small Volume Parenteral (or SVI-Small Volume Injection)is an injection that is packaged in containers labelled as containing not more than 100ml. Under the class of SVP/SVI there are, consequently, all the sterile products packaged in vials, ampoules, cartridge, syringes, bottles (or any other container that is 100ml or less). Ophthalmic products packaged in squeezable containers, although topically applied to the eyes (and not administered by injection), also fall under Small Volume Injections (SVI) classification.

Small volume parenteral products can be formulated and packaged in several ways and include a wide range of products like biological products, allergenic extracts, liposome and lipid products, radiopharmaceutical products,genetically engineered or biotechnology products, The injection is a preparation intended for parenteral administration and/or diluting/constituting a parenteral. Examples of preparations: drug injection, injectable emulsion, injectable suspension, drug for injection, drug for injectable suspension.